The growth hormone axis and insulin-like growth factors
نویسندگان
چکیده
منابع مشابه
The growth hormone-insulin-like growth factor-I axis.
The aim of the GH-2000 project is to develop a method for detecting GH doping among athletes. Previous papers in the GH-2000 project have proposed that a forthcoming method to detect GH doping will need specific components from the GH/IGF-I axis and bone markers because these specific variables seem more sensitive to exogenous GH than to exercise. The present study examined the responses of the...
متن کاملGrowth hormone, insulin-like growth factors, and the skeleton.
GH and IGF-I are important regulators of bone homeostasis and are central to the achievement of normal longitudinal bone growth and bone mass. Although GH may act directly on skeletal cells, most of its effects are mediated by IGF-I, which is present in the systemic circulation and is synthesized by peripheral tissues. The availability of IGF-I is regulated by IGF binding proteins. IGF-I enhanc...
متن کاملDisturbances of growth hormone-insulin-like growth factor axis and response to growth hormone in acidosis.
Severe chronic metabolic acidosis (CMA) in rats is associated with poor food intake and downregulation of growth hormone (GH), insulin-like growth factors (IGFs), and liver receptors; the administration of recombinant GH (rGH) fails to improve the growth failure. In mice with carbonic anhydrase II deficiency (CAD), a model of moderate CMA with food intake close to normal, we studied serum level...
متن کاملInsulin like growth factors and growth hormone deficiency.
polypeptides that act as endocrine mediators of growth hormone (GH)-induced actions. They also function in a paracrine and autocrine manner to regulate cell growth, differentiation, apoptosis and transformation. The IGF system is a complex network comprised of two growth factors (IGF-I and -II), cell surface receptors (IGF-IR and -IIR), high affinity binding proteins (IGFBP), IGFBP proteases as...
متن کاملThe Growth Hormone/Insulin-Like Growth Factor-I Axis in Exercise and Sport.
The syndrome of adult GH deficiency and the effects of GH replacement therapy provide a useful model with which to study the effects of the GH/IGF-I axis on exercise physiology. Measures of exercise performance including maximal oxygen uptake and ventilatory threshold are impaired in adult GH deficiency and improved by GH replacement, probably through some combination of increased oxygen delive...
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ژورنال
عنوان ژورنال: Medicinski pregled
سال: 2005
ISSN: 0025-8105,1820-7383
DOI: 10.2298/mpns0512558r